[20170912]IN10773_胚胎CRISPR基因编辑研究引发科学和伦理争论.pdf

CRS INSIGHT Prepared for Members and Committees of Congress CRISPR Gene Editing Research in Embryos Generates Scientific and Ethics Debate John F. Sargent Jr. Specialist in Science and Technology Policy Amanda K. Sarata Specialist in Health Policy Judith A. Johnson Specialist in Biomedical Policy September 12, 2017 A recent experiment in the United States using the gene modification tool CRISPR to target a disease gene in human embryos has raised optimism about promising medical advances, generated scientific debate, and renewed debate about long-standing ethical issues. Since 1996, Congress has prohibited the use of funds appropriated in the Labor-HHS-Education appropriations bill for “the creation of a human embryo or embryos for research purposes” or for “research in which a human embryo or embryos are destroyed, discarded, or knowingly subjected to risk of injury or death greater than that allowed for research on fetuses in utero under federal law and regulations.” Use of private funds for such basic research is not prohibited. Implantation of CRISPR modified embryos as part of a clinical research study is essentially blocked, regardless of funding source, since Congress began